Human Cell Transformation

Human Cell Transformation

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Rhim and Kremera€™s state-of-the-art volume on Human Cell Transformation: Role of Stem Cells and the Microenvironment highlights the latest findings on the current state of human cell transformation model systems and provides the insight into the molecular and cellular changes involved in the conversion of normal cells to neoplastic cells. Chapters cover all recently developed novel human cell models. In addition, the rapidly growing fields of knowledge regarding not only stem cells in cancer progression, but also the role of the microenvironments in human carcinogenesis are discussed. A wealth of topics is presented including: Am Derivation of epithelial, fibroblastic, and hematopoietic in vitro model systems Am Oncogenes Am Tumor suppressor genes Am Viral transformation Am In vitro model systems for viral, chemical and radiation carcinogenesis Am Cell aging Am The multistep nature of human carcinogenesis Am The role of stem cells and the microenvironment in tumorigenesis Am The genes involved in multistep carcinogenesis Unique in both scope and focus a€“ devoted solely to human cell transformation systems a€“ Human Cell Transformation: Role of Stem Cells and the Microenvironment provides unparalleled, in-depth coverage for cancer researchers, cell and molecular biologists, hematologists, virologists, and workers in related fields. Essential reading for everyone who needs to be kept up-to-date in this fast-paced area! Features On Multistep models On Breast cancer/Stem cells On Prostate cancer/Stem cells On Multistep / GenesTheir total RNA was extracted using TRIZOL reagent (Invitrogen) according to the manufacturera#39;s instructions. ... 5.2.17 Quantitative Real-Time PCR Quantitative real-time PCR was carried out on an ABI 7500 real-time PCR system usinganbsp;...

Title:Human Cell Transformation
Author: Johng S. Rhim, Richard Kremer
Publisher:Springer Science & Business Media - 2011-09-15

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