Quantitative Proteomic Method Development for the Analysis of the Intact Human Heart

Quantitative Proteomic Method Development for the Analysis of the Intact Human Heart

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Dilated cardiomyopathy (DCM), the most common form of heart failure, is characterized by an increase heart size, a process known as cardiac remodeling. Much is still unknown about the molecular basis of the progression of DCM and the cellular changes associated with current pharmacological beta-blocker treatment, which results in a reversal of the remodeling process. To begin to address these questions, Drs. Michael Bristow and Brian Lowes at the University of Colorado, are looking at mRNA expression differences in human patients prior to and during pharmacological treatment using a range of beta-blocking drugs. Concurrent analysis of genomic and proteomic changes in these patient samples would provide a more comprehensive view of the molecular changes occurring during drug treatment. However, proteomic methods for the analysis of mRNA-extracted human tissues have not been developed.Bristow, M. R.; Feldman, A. M.; Adams, K. R, Jr.; Goldstein, S., Selective versus nonselective beta-blockade for heart failure therapy: are there ... Francis, G. S.; Simon, A. B.; Rector, T., Plasma norepinephrine as a guide to prognosis in patients with chronic congestive heart failure. ... Ruse, C. I.; Tan, F. L.; Kinter, M; Bond, 297.


Title:Quantitative Proteomic Method Development for the Analysis of the Intact Human Heart
Author: Kelli Gail Kline
Publisher:ProQuest - 2009
ISBN-13:

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